Pump Up the Volume: Could Excessive Neural Gain Explain Tinnitus and Hyperacusis? (Record no. 2469)
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| 000 -LEADER | |
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| fixed length control field | 02114nam a22001697a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20150710154459.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 150710b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | National Acoustic Laboratories |
| 245 ## - TITLE STATEMENT | |
| Title | Pump Up the Volume: Could Excessive Neural Gain Explain Tinnitus and Hyperacusis? |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc | Naturally occurring stimuli can vary over several orders of<br/>magnitude and may exceed the dynamic range of sensory<br/>neurons. As a result, sensory systems adapt their sensitivity<br/>by changing their responsiveness or ‘gain’. While many peripheral<br/>adaptation processes are rapid, slow adaptation<br/>processes have been observed in response to sensory deprivation<br/>or elevated stimulation. This adaptation process alters<br/>neural gain in order to adjust the basic operating point<br/>of sensory processing. In the auditory system, abnormally<br/>high neural gain may result in higher spontaneous and/or<br/>stimulus-evoked neural firing rates, and this may have the<br/>unintended consequence of presenting as tinnitus and/or<br/>sound intolerance, respectively. Therefore, a better understanding<br/>of neural gain, in health and disease, may lead to<br/>more effective treatments for these aberrant auditory perceptions.<br/>This review provides a concise summary of (i) evidence<br/>for changes in neural gain in the auditory system of<br/>animals, (ii) physiological and perceptual changes in adult<br/>human listeners following an acute period of enhanced<br/>acoustic stimulation and/or deprivation, (iii) physiological<br/>evidence of excessive neural gain in tinnitus and hyperacusis<br/>patients, and (iv) the relevance of neural gain in the clinical<br/>treatment of tinnitus and hyperacusis. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Gain · Plasticity · Tinnitus · Hyperacusis · Homoeostatic plasticity · Hearing loss |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hannah Brotherton |
| 773 0# - HOST ITEM ENTRY | |
| Relationship information | June 2015;20:4 p 273–282 |
| Title | Audiolology Neurotology |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://dspace.nal.gov.au/xmlui/bitstream/handle/123456789/213/Pump%20up%20the%20volume%20could%20excessive%20neural%20gain%20explain%20tinnitus%20and%20hyperacusis.pdf?sequence=1&isAllowed=y">http://dspace.nal.gov.au/xmlui/bitstream/handle/123456789/213/Pump%20up%20the%20volume%20could%20excessive%20neural%20gain%20explain%20tinnitus%20and%20hyperacusis.pdf?sequence=1&isAllowed=y</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Universal Decimal Classification |
| Koha item type | Journal article |
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