The absence of resting-state high-gamma cross-frequency coupling in patients with tinnitus (Record no. 2832)
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| 000 -LEADER | |
|---|---|
| fixed length control field | nam a22 7a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20171207162131.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 171207b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | National Acoustics Laboratories |
| 245 ## - TITLE STATEMENT | |
| Title | The absence of resting-state high-gamma cross-frequency coupling in patients with tinnitus |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc | Tinnitus is a psychoacoustic phantom perception of currently unknown neuropathology. Despite a<br/>growing number of post-stimulus tinnitus studies, uncertainty still exists regarding the neural signature<br/>of tinnitus in the resting-state brain. In the present study, we used high-gamma cross-frequency coupling<br/>and a Granger causality analysis to evaluate resting-state electroencephalographic (EEG) data in healthy<br/>participants and patients with tinnitus. Patients with tinnitus lacked robust frontal delta-phase/central<br/>high-gamma-amplitude coupling that was otherwise clearly observed in healthy participants. Since<br/>low-frequency phase and high-frequency amplitude coupling reflects inter-regional communication<br/>during cognitive processing, and given the absence of frontal modulation in patients with tinnitus, we<br/>hypothesized that tinnitus might be related to impaired prefrontal top-down inhibitory control. A<br/>Granger causality analysis consistently showed abnormally pronounced functional connectivity of lowfrequency<br/>activity in patients with tinnitus, possibly reflecting a deficiency in large-scale communication<br/>during the resting state. Moreover, different causal neurodynamics were characterized across two<br/>subgroups of patients with tinnitus; the T1 group (with higher P300 amplitudes) showed abnormal<br/>frontal-to-auditory cortical information flow, whereas the T2 group (with lower P300 amplitudes)<br/>exhibited abnormal auditory-to-frontal cortical information control. This dissociation in resting-state<br/>low-frequency causal connectivity is consistent with recent post-stimulus observations. Taken<br/>together, our findings suggest that maladaptive neuroplasticity or abnormal reorganization occurs in the<br/>auditory default mode network of patients with tinnitus. Additionally, our data highlight the utility of<br/>resting-state EEG for the quantitative diagnosis of tinnitus symptoms and the further characterization of<br/>tinnitus subtypes. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Min-Hee Ahn |
| 773 0# - HOST ITEM ENTRY | |
| Relationship information | xxx (2017) 1e11 |
| Title | Hearing Research |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://dspace.nal.gov.au/xmlui/bitstream/handle/123456789/778/The%20absence%20of%20resting%20-%20state%20high%20-%20gamma%20cross%20-frequency%20coupling.pdf?sequence=1&isAllowed=y">https://dspace.nal.gov.au/xmlui/bitstream/handle/123456789/778/The%20absence%20of%20resting%20-%20state%20high%20-%20gamma%20cross%20-frequency%20coupling.pdf?sequence=1&isAllowed=y</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Universal Decimal Classification |
| Koha item type | Journal article |
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