Characteristics of cochlear microphonics in infants and young children with auditory neuropathy (Record no. 2898)
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| fixed length control field | 02801nam a22001577a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20180620160609.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 180620b ||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | National Acoustics Laboratories |
| 245 ## - TITLE STATEMENT | |
| Title | Characteristics of cochlear microphonics in infants and young children with auditory neuropathy |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc | Conclusions: Cochlear microphonics (CMs) play an important role in the diagnosis of auditory neuropathy (AN). It is necessary<br/>and helpful to diagnose the sites-of-lesion in infants and children with AN by analyzing the patterns of CM amplitudes and I/O<br/>functions together. Objectives: To investigate the characteristics and clinical significance of CMs in the diagnosis of AN among<br/>infants and children. Methods: A total of 36 infants and children (16 males and 20 females) were divided into two groups.<br/>Group A included 15 children (30 ears) with auditory brainstem response (ABR) absent and distortion product otoacoustic<br/>emissions (DPOAEs) present and group B included 21 children (30 ears) with ABR absent and DPOAEs absent. Fifteen<br/>normal-hearing infants (30 ears) made up the control group. Click eliciting CMs were recorded at stimulus levels of 100, 90,<br/>80, and 70 dB nHL for each ear using a button electrode placed at the top of the forehead. A tube-clamping method was used to<br/>distinguish CMs from artifacts, and an averaging algorithm was used to obtain a clear CM waveform. The time delay and<br/>amplitude of CMs were measured in both children with AN and normal-hearing infants on (C–R)/2 waveforms, and an I/O<br/>function curve for each group was plotted with the stimulating level as input and the CM amplitude as output. Results: The<br/>largest identifiable CMs were generally found between 0.5 and 0.8 ms after stimulation with mean delay of 0.63 ± 0.04 ms in<br/>both group A and the control group, and 0.63 ± 0.07 ms in group B. There was no significant difference between the AN group<br/>and the control group in CM time delay. There was no significant difference (p > 0.05) between group A (AN with OAEs<br/>present, 0.47 ± 0.15 mV) and the control group (0.45 ± 0.13 mV) in CM amplitude, while CM amplitudes in children with AN<br/>with DPOAEs absent (0.24 ± 0.08 mV) were significantly lower than those in either the control group or group A (p < 0.01).<br/>The amplitude of CMs reduced with stimulus intensity in all the subjects. There was obvious nonlinearity in group A and the<br/>control group, while there was a more linear tendency in amplitude increasing on the I/O function curve in group B. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Cochlear microphonics, auditory neuropathy, vestibulocochlear nerve diseases, evoked potentials, auditory brainstem, hearing loss |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wei Shi |
| 773 0# - HOST ITEM ENTRY | |
| Relationship information | (September 2011) |
| Title | Acta Oto-Laryngologica |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Universal Decimal Classification |
| Koha item type | Journal article |
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