TY  - BOOK
AU  - Sharma, Anu
AU  -  Garrett Cardon
TI  - Cortical development and neuroplasticity in Auditory Neuropathy Q7 Spectrum Disorder
KW  - Auditory Neuropathy Spectrum Disorder (ANSD) Cortical auditory evoked potentials (CAEP) P1 biomarker Cortical phase synchrony Inter-trial coherence (ITC) Current density reconstruction Source analysis Cochlear implants Hearing aids High-density EEG
N2  - Cortical development is dependent to a large extent on stimulus-driven input. Auditory Neuropathy
Spectrum Disorder (ANSD) is a recently described form of hearing impairment where neural dyssynchrony
is the predominant characteristic. Children with ANSD provide a unique platform to
examine the effects of asynchronous and degraded afferent stimulation on cortical auditory neuroplasticity
and behavioral processing of sound. In this review, we describe patterns of auditory cortical
maturation in children with ANSD. The disruption of cortical maturation that leads to these various
patterns includes high levels of intra-individual cortical variability and deficits in cortical phase synchronization
of oscillatory neural responses. These neurodevelopmental changes, which are constrained
by sensitive periods for central auditory maturation, are correlated with behavioral outcomes for children
with ANSD. Overall, we hypothesize that patterns of cortical development in children with ANSD
appear to be markers of the severity of the underlying neural dys-synchrony, providing prognostic indicators
of success of clinical intervention with amplification and/or electrical stimulation.
This article is part of a Special Issue entitled <Auditory Synaptology>
UR  - http://dspace.nal.gov.au/xmlui/bitstream/handle/123456789/211/Cortical%20development%20and%20neuroplasticity%20in%20auditory%20neuropathy%20spectrum%20disorder.pdf?sequence=1&isAllowed=y
ER  -