000			02894naa a22002417a 4500
003			OSt
005			20150123124812.0
008			150123b xxu||||| |||| 00| 0 eng d
040			_cNational Acoustic Laboratory
245			_aAltered Cortical Activity in Prelingually Deafened Cochlear Implant Users Following Long Periods of Auditory Deprivation
520	3		_aAuditory stimulation during childhood is critical for the development of the auditory cortex in humans and with that for hearing in adulthood. Age-related changes in morphology and peak latencies of the cortical auditory evoked potential (CAEP) have led to the use of this cortical response as a biomarker of auditory cortical maturation including studies of cortical development after deafness and subsequent cochlear implantation. To date, it is unknown whether prelingually deaf adults, with early onset deafness (before the age of 2 years) and who received a cochlear implant (CI) only during adulthood, would display absent or aberrant CAEP waveforms as predicted from CAEP studies in late implanted prelingually deaf children. In the current study, CAEP waveforms were recorded in response to electric stimuli in prelingually deaf adults, who received their CI after the age of 21 years. Waveform morphology and peak latencies were compared to the CAEP responses obtained in postlingually deaf adults, who became deaf after the age of 16. Unexpectedly, typical CAEP waveforms with adult-like P1-N1-P2 morphology could be recorded in the prelingually deaf adult CI users. On visual inspection, waveform morphology was comparable to the CAEP waveforms recorded in the postlingually deaf CI users. Interestingly, however, latencies of the N1 peak were significantly shorter and amplitudes were significantly larger in the prelingual group than in the postlingual group. The presence of the CAEP together with an early and large N1 peak might represent activation of the more innate and less complex components of the auditory cortex of the prelingually deaf CI user, whereas the CAEP in postlingually deaf CI users might reflect activation of the mature neural network still present in these patients. The CAEPs may therefore be helpful in the assessment of developmental state of the auditory cortex.
650			_acortical auditory evoked potential,
650			_adeafness _9513
650			_a cochlear implant _91015
650			_aplasticity
650			_aauditory cortex
650			_a prelingual deaf
650			_a hearing loss _9720
700			_aMARC J. W. LAMMERS,1,2
773	0		_g2014 _tJARO
856			_uhttp://dspace.nal.gov.au/xmlui/bitstream/handle/123456789/87/Altered%20cortical%20activity%20in%20%20prelingually%20deafened%20cochlear%20implant%20users%20following%20long%20periods%20of%20auditory%20deprivation.pdf?sequence=1&isAllowed=y
942			_2udc _cJOURNALS
999			_c2363 _d2363