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040 _cNational Acoustic Laboratory
100 _a Nash-Kille, Amy
245 _aInter-trial coherence as a marker of cortical phase synchrony in children with sensorineural hearing loss and auditory neuropathy spectrum disorder fitted with hearing aids and cochlear implants
520 3 _aObjective: Although brainstem dys-synchrony is a hallmark of children with auditory neuropathy spectrum disorder (ANSD), little is known about how the lack of neural synchrony manifests at more central levels. We used time–frequency single-trial EEG analyses (i.e., inter-trial coherence; ITC), to examine cortical phase synchrony in children with normal hearing (NH), sensorineural hearing loss (SNHL) and ANSD. Methods: Single trial time–frequency analyses were performed on cortical auditory evoked responses from 41 NH children, 91 children with ANSD and 50 children with SNHL. The latter two groups included children who received intervention via hearing aids and cochlear implants. ITC measures were compared between groups as a function of hearing loss, intervention type, and cortical maturational status. Results: In children with SNHL, ITC decreased as severity of hearing loss increased. Children with ANSD revealed lower levels of ITC relative to children with NH or SNHL, regardless of intervention. Children with ANSD who received cochlear implants showed significant improvements in ITC with increasing experience with their implants.
773 0 _g125 (2014) 1459–1470
_tClinical Neurophysiology
856 _uhttp://dspace.nal.gov.au/xmlui/bitstream/handle/123456789/138/Inter-trial%20coherence%20as%20a%20marker%20of%20cortical%20phase%20synchrony%20in%20children%20with%20sensorineural%20hearing%20loss%20and%20auditory%20neuropathy%20spectrum%20disorder%20fitted%20with%20hearing%20aids%20and%20cochlear%20implantspdf.pdf?sequence=1&isAllowed=y
942 _2udc
_cARTICLE
999 _c2396
_d2396