000			02350nam a22001697a 4500
003			OSt
005			20150529142028.0
008			150529b xxu||||| |||| 00| 0 eng d
040			_cNational Acoustic Laboratories
245			_aAuditory neural myelination is associated with early childhood language development in premature infants
520	3		_aBackground: Auditory neural myelination (ANM) as evaluated by auditory brainstem evoked response (ABR) during the neonatal period has been used as a surrogate outcome for long-termneurodevelopment. The validity of ANM as a surrogate outcome for long-term neurodevelopment has not been well studied. Aim: Evaluate the association of ABR I–V interpeak latency (IPL), an index of ANM, at 35 week postmenstrual age (PMA) with language outcome at 3 years of age. Design: Prospective study. Subjects: 24–33 week gestational age (GA) infants were eligible if they did not meet exclusion criteria: craniofacial malformation, chromosomal disorders, deafness, auditory dys-synchrony, TORCH infection, or non-English speaking parents. Infants with malignancy, head injury, encephalopathy, meningitis, blindness, or who died or relocated were also excluded. Outcomemeasures: ABRs were performed at 35week PMAusing 80 dB nHL and I–V IPL (ms) measured. Auditory Comprehension (AC) and Expressive Communication (EC) were evaluated by a speech-language pathologist at 3 years of age using Preschool Language Scale. Results: Eighty infants were studied. The mean GA and birth weight of infants were 29.2 weeks and 1336 g, respectively. There was association of worse ear I–V IPL and better ear I–V IPL with AC (Coefficient−5.4, 95% CI: −9.8 to −0.9 and Coefficient−5.5, 95% CI: −10 to−0.9, respectively) and EC (Coefficient−5.6, 95% CI: −9.5 to−1.8 and Coefficient−6.7, 95% CI: −10.6 to−2.7, respectively) after controlling for confounders. Conclusion: The neonatal I–V IPL is a predictor of language development at 3 years of age in preterms.
650			_aMyelination Interpeak latency Nerve conduction velocity Neurodevelopment
700			_aSanjiv B. Amin
773	0		_g90 (2014) 673–678 _tEarly Human Development
856			_uhttp://dspace.nal.gov.au/xmlui/bitstream/handle/123456789/176/Auditory%20neural.pdf?sequence=1&isAllowed=y
942			_2udc _cJOURNALS
999			_c2437 _d2437