000			01997nam a22001697a 4500
003			OSt
005			20151016160940.0
008			151016b xxu||||| |||| 00| 0 eng d
040			_cNational Acoustic Laboratories
100			_aXua,b , Qin
245			_aTemporal integration reflected by frequency following response in auditory brainstem
520	3		_aAuditory temporal integration (ATI) has been widely described in psychoacoustic studies, especially for loudness perception. Loudness increases with increasing sound duration for durations up to a time constant about 100 ~ 200 ms, and then loudness becomes saturated with more duration increase. However, the electrophysiological mechanism underlying the ATI phenomenon has not been well understood. To investigate ATI at the brainstem level of auditory system and its relationship to cortical and behavioral ATI, frequency follow response (FFR) was acquired in our study. Simultaneously, ATI in auditory cortex was evaluated by cortical response P1. Behavioral loudness and electrophysiological measures were estimated from normal-hearing young adults for vowel /a/ whose durations varied from 50 ms to 175 ms. Significant effects of stimulus duration were found both on FFR and P1 amplitudes. Linear regression analysis revealed that as stimulus duration increased, brainstem FFR amplitude was significantly associated with cortical P1 amplitude and behavioral loudness, which confirmed the existence of temporal integration in auditory brainstem. Moreover, behavioral loudness ATI was better predicted using brainstem and cortical measures together than merely using each one separately, indicating an interplay and coordination for ATI across the three levels along auditory pathway.
650			_aAuditory temporal integration (ATI), frequency following response (FFR), cortical response P1, loudness
700			_aDatian Yea,
773	0		_g26 (2015) S767–S778 _tBio-Medical Materials and Engineering
942			_2udc _cARTICLE
999			_c2503 _d2503