000			nam a22 7a 4500
999			_c2843 _d2843
003			OSt
005			20180124160954.0
008			180124b ||||| |||| 00| 0 eng d
040			_cNational Acoustics Laboratories
245			_aChildren with autism spectrum disorder have unstable neural responses to sound
520	3		_aAutism spectrum disorder (ASD) is diverse, manifesting in a wide array of phenotypes. However, a consistent theme is reduced communicative and social abilities. Auditory processing deficits have been shown in individuals with ASD—these deficits may play a role in the communication difficulties ASD individuals experience. Specifically, children with ASD have delayed neural timing and poorer tracking of a changing pitch relative to their typically developing peers. Given that accurate processing of sound requires highly coordinated and consistent neural activity, we hypothesized that these auditory processing deficits stem from a failure to respond to sound in a consistent manner. Therefore, we predicted that individuals with ASD have reduced neural stability in response to sound. We recorded the frequency-following response (FFR), an evoked response that mirrors the acoustic features of its stimulus, of high-functioning children with ASD age 7–13 years. Evident across multiple speech stimuli, children with ASD have less stable FFRs to speech sounds relative to their typically developing peers. This reduced auditory stability could contribute to the language and communication profiles observed in individuals with ASD.
650			_aAutism spectrum disorder · Neural stability · Neural variability · FFR · Auditory · Sound processing
700			_aSebastian Otto-Meyer
773	0		_g(January 2018) _tExperimental Brain Research
856			_uhttps://dspace.nal.gov.au/xmlui/bitstream/handle/123456789/784/Children%20with%20autism%20spectrum%20disorder%20have%20unstable%20neural%20responses%20to%20sound.pdf?sequence=1&isAllowed=y
942			_2udc _cARTICLE