000			02135nam a22001817a 4500
999			_c2879 _d2879
003			OSt
005			20180608141900.0
008			180608b ||||| |||| 00| 0 eng d
040			_cNational Acoustics Laboratories
100			_aBrandon, Paul T
245			_aTowards an objective test of chronic tinnitus: Properties of auditory cortical potentials evoked by silent gaps in tinnitus-like sounds
520	3		_aA common method designed to identify if an animal hears tinnitus assumes that tinnitus “fills-in” silent gaps in background sound. This phenomenon has not been reliably demonstrated in humans. One test of the gap-filling hypothesis would be to determine if gap-evoked cortical potentials are absent or attenuated when measured within background sound matched to the tinnitus sensation. However the tinnitus sensation is usually of low intensity and of high frequency, and it is unknown if cortical responses can be measured with such “weak” stimulus properties. Therefore the aim of the present study was to test the plausibility of observing these responses in the EEG in humans without tinnitus. Twelve non-tinnitus participants heard narrowband noises centered at sound frequencies of 5 or 10 kHz at sensation levels of either 5, 15, or 30 dB. Silent gaps of 20 ms duration were randomly inserted into noise stimuli, and cortical potentials evoked by these gaps were measured by 64-channel EEG. Gap-evoked cortical responses were statistically identifiable in all conditions for all but one participant. Responses were not significantly different between noise frequencies or levels. Results suggest that cortical responses can be measured when evoked by gaps in sounds that mirror acoustic properties of tinnitus. This design can validate the animal model and be used as a tinnitus diagnosis test in humans.
700			_aMarc Schoenwiesner
700			_aSylvie Hebert
773	0		_gApril 2018 _tHearing Research
856			_uhttps://dspace.nal.gov.au/xmlui/bitstream/handle/123456789/905/Towards%20an%20objective%20test%20of%20chronic%20tinnitus.pdf?sequence=1&isAllowed=y
942			_2udc _cARTICLE